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CK 666
CAS No. 442633-00-3
CK 666 ( CK 0944666 )
产品货号. M14508 CAS No. 442633-00-3
CK 666 (CK 0944666) 是一种小分子 Arp2/3 复合物抑制剂，IC50 为 4 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥640 | 有现货 |
|
| 10MG | ￥1158 | 有现货 |
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| 25MG | ￥2398 | 有现货 |
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| 50MG | ￥4641 | 有现货 |
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| 100MG | ￥6440 | 有现货 |
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| 200MG | ￥8060 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CK 666
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CK 666 (CK 0944666) 是一种小分子 Arp2/3 复合物抑制剂，IC50 为 4 uM。
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产品描述CK 666 (CK 0944666) is a small molecule Arp2/3 complex inhibitor with IC50 of 4 uM, inhibits actin polymerization with either BtArp2/3 complex (IC50=17 uM) or SpArp2/3 complex (IC50=5 uM); reduces actin polymerization around intracellular Listeria to background levels (Fig. 2e and g) at lower concentrations than CK-636; alters the morphology and slightly slowed but did not stop the gliding motility of fish keratocytes.
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体外实验CK-666 (100 μM) significantly reduces the number of filopodia on the cell surface of treated trabecular meshwork (TM) cells as well as reduces the length of those filopodia that are present.
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体内实验——
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同义词CK 0944666
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通路Cytoskeleton/Cell Adhesion Molecules
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靶点Arp2/3 complex
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受体Arp2/3 complex
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研究领域——
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适应症——
化学信息
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CAS Number442633-00-3
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分子量296.345
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分子式C18H17FN2O
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纯度>98% (HPLC)
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溶解度DMSO : 125 mg/mL 421.81 mM
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SMILESCC1=C(C2=CC=CC=C2N1)CCNC(=O)C3=CC=CC=C3F
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化学全称2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Hetrick B, et al. Chem Biol. 2013 May 23;20(5):701-12.
2. Nolen BJ, et al. Nature. 2009 Aug 20;460(7258):1031-4.
3. Yi K, et al. Nat Cell Biol. 2011 Aug 28;13(10):1252-8.
